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On-Demand

CSEM Stream

CSEMS1 - Premature Ovarian Insufficiency

Thursday, November 27, 2025
10:30 - 11:45 Toronto
Location: Room 206

    Speaker(s)

  • Iliana C. Lega, MD Msc (she/her/hers)

    Endocrinologist
    Women’s College Hospital
    University of Toronto
    Toronto, Ontario, Canada

    Disclosure(s): I do not have a relationship with a for-profit and/or a not-for-profit organization to disclose

  • MJ

    Michelle Jacobson, MD, FRCSC, MHSc, MSCP (she/her/hers)

    OBGYN
    Coven Women's Health
    University of Toronto
    Toronto, Ontario, Canada

    Disclosure(s): Abbvie: Advisory Board (Ongoing), Speaker/Honoraria (Ongoing); Astellas: Advisory Board (Ongoing), Consultant (Ongoing), Speaker/Honoraria (Ongoing); Bayer: Advisory Board (Ongoing), Consultant (Ongoing), Speaker/Honoraria (Ongoing); BioSyent: Advisory Board (Ongoing), Speaker/Honoraria (Ongoing); duchesnay: Advisory Board (Ongoing), Consultant (Ongoing), Speaker/Honoraria (Ongoing); Eisai: Advisory Board (Ongoing); Hologic, Inc: Speaker/Honoraria (Ongoing); Idorsia: Advisory Board (Ongoing), Consultant (Ongoing), Speaker/Honoraria (Ongoing); knight: Advisory Board (Ongoing), Consultant (Ongoing), Speaker/Honoraria (Ongoing); kye: Advisory Board (Ongoing), Speaker/Honoraria (Ongoing); Lilly: Speaker/Honoraria (Ongoing); Lupin: Advisory Board (Ongoing), Consultant (Ongoing), Speaker/Honoraria (Ongoing); Pfizer: Advisory Board (Ongoing), Consultant (Ongoing), Speaker/Honoraria (Ongoing); searchlight: Advisory Board (Ongoing), Consultant (Ongoing), Speaker/Honoraria (Ongoing)

    • Moderator(s)

  • Donna VINE, BSc Hon PhD (she/her/hers)

    Professor
    U of Alberta, PCOS Together Lab
    U of Alberta
    Edmonton, Alberta, Canada

    Disclosure(s): Canadian Sugar Institute: Advisory Board (Ongoing); Heart and Stroke Foundation: Grant/Research Support (Ongoing); Women and Children's Health Research Institute: Grant/Research Support (Ongoing)

Disclosure(s):
Iliana C. Lega, MD Msc: I do not have a relationship with a for-profit and/or a not-for-profit organization to disclose
Michelle Jacobson: Abbvie: Advisory Board (Ongoing), Speaker/Honoraria (Ongoing); Astellas: Advisory Board (Ongoing), Consultant (Ongoing), Speaker/Honoraria (Ongoing); Bayer: Advisory Board (Ongoing), Consultant (Ongoing), Speaker/Honoraria (Ongoing); BioSyent: Advisory Board (Ongoing), Speaker/Honoraria (Ongoing); duchesnay: Advisory Board (Ongoing), Consultant (Ongoing), Speaker/Honoraria (Ongoing); Eisai: Advisory Board (Ongoing); Hologic, Inc: Speaker/Honoraria (Ongoing); Idorsia: Advisory Board (Ongoing), Consultant (Ongoing), Speaker/Honoraria (Ongoing); knight: Advisory Board (Ongoing), Consultant (Ongoing), Speaker/Honoraria (Ongoing); kye: Advisory Board (Ongoing), Speaker/Honoraria (Ongoing); Lilly: Speaker/Honoraria (Ongoing); Lupin: Advisory Board (Ongoing), Consultant (Ongoing), Speaker/Honoraria (Ongoing); Pfizer: Advisory Board (Ongoing), Consultant (Ongoing), Speaker/Honoraria (Ongoing); searchlight: Advisory Board (Ongoing), Consultant (Ongoing), Speaker/Honoraria (Ongoing)
Donna VINE, BSc Hon PhD: Canadian Sugar Institute: Advisory Board (Ongoing); Heart and Stroke Foundation: Grant/Research Support (Ongoing); Women and Children's Health Research Institute: Grant/Research Support (Ongoing)

Learning Objectives:

  • Summarize the etiologies, clinical features, and diagnostic criteria for premature ovarian insufficiency, including genetic, autoimmune, and iatrogenic causes;
  • Critically assess the quality, strengths, and limitations of clinical trials and observational studies evaluating the efficacy and safety of hormone replacement strategies in women with POI;
  • Apply an evidence-based approach to selecting and individualizing hormone replacement therapy for patients with POI, considering factors such as age of diagnosis, comorbidities, route of administration, and long-term health outcomes.