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On-Demand

CSEM Stream

CSEMS4 - Dyslipidemia: Interpretation of genetic reports

Friday, November 28, 2025
16:00 - 17:15 Toronto
Location: Room 205

    Speaker(s)

  • MP

    Marie Pigeyre, MD PhD (she/her/hers)

    Associate Professor
    McMaster University
    Hamilton, Ontario, Canada

    Disclosure(s): I do not have a relationship with a for-profit and/or a not-for-profit organization to disclose

    • Moderator(s)

  • Yuan Kong, MD (she/her/hers)

    Physician
    Markham Diabetes
    Markham, Ontario, Canada

    Disclosure(s): I do not have a relationship with a for-profit and/or a not-for-profit organization to disclose

Disclosure(s):
Marie Pigeyre, MD PhD: I do not have a relationship with a for-profit and/or a not-for-profit organization to disclose
Learning Objectives: This session will:
1. Define and discuss the specific lipid disorders and clinical scenarios where genetic testing is clinically indicated, including familial hypercholesterolemia (FH) and other rare monogenic dyslipidemias.
2. Evaluate and interpret the clinical relevance of genetic mutations associated with dyslipidemia, with a focus on autosomal recessive (AR) and autosomal dominant (AD) inheritance patterns, the implications of variants of undetermined significance (VUS), and the role of variable penetrance in the expression of lipid disorders.
3. Outline the necessary follow-up steps and additional clinical workup after the identification of genetic changes associated with lipid disorders, including guidelines on familial screening for different genetic variations to identify at-risk family members and manage early detection."